TB is a synthetic fraction of the protein thymosin beta-4, which is present in virtually all human and animal cells. The main purpose of this peptide is to promote healing. It also promotes creation of new blood and muscle cells.
The healing effects of TB have been observed in tendons, ligaments, muscle, skin, heart, and the eyes. Thymosin beta-4 is naturally produced in higher concentration where tissue has been damaged. This peptide is also a very potent anti-inflamatory agent. TB is different from other repair factors growth hormone, IGF-1because it promotes endothelial and keratinocyte migration. It also does not startrack depot to the extracellular matrix and has a very low molecular weight.
Because of this it can travel long distances through the tissues in the human body. One of TB key mechanisms of action is its ability to regulate the cell-building protein - Actin. It is thus a vital component of cell structure and movement. It has been studies in numerous clinical trials. Research has shown that if the thymosin beta-4 peptide is used after a heart attack it can reactivate cardiac progenitor cells to repair damaged heart tissue.
Thymosin beta-4 is a very large molecule. In fact, it is so large that it cannot fit entirely into the receptor. Different sections of the molecule have different activities. TB is the part of thymosin beta-4 hormone which promotes the most useful effects overall healing, repair, new blood and muscle cells. For medical applications it is more practical to use the TB instead of the entire Thymosin Beta-4 protein. Alternatively it can be reconstituted with sterile saline 0.
Plain sterile water should be readily available to buy without prescription in any local pharmacy. Alternatively it can also be purchased online. It is even available on ebay. Syringes: The insulin type syringe with markings on the side should be used. They are readily available in any local pharmacy store. How to mix reconstitute the TB Pull 1ml of water into the syringe and inject it into the vial with powder.
You should never shake the vial when mixing. You should not inject the water directly into the powder with force, but rather let it gently slide down the inside of the vial. If it bubbles up, you should put the vial in the refrigerator and leave it there for about minutes.
The bubbles will be gone by then. You should then gently rotate the vial between your fingers until all of the powder has dissolved it takes about minutes. The vials are under vacuum, so before you can take the tb out, you need to release the vacuum.
Take a fresh syringe, pull air into it and inject the air into the vial not into liquid, but into air above the liquid. This will get rid of the vacuum.
You can then pull out the reconstituted tb as needed. TB Injection spot and procedure: The tb has a systematic effect regardless of where it is injected. Some believe that thymosin beta-4 should be injected as close to the injury as possible however there is no evidence to show this would be superior.
It can be injected subcutaneously stomach fat or intramuscularly shoulders, thighs, buttocks. Injections should be given in different sites rotated each time.T cell production and action within the body is vital to adaptive immunity.
This is the mode by which immune cells are able to recognize and kill foreign invaders. T cells, for example, come in two forms: killer and helper T cells. Helper cells work with the other cells of the immune system to orchestrate and carry out appropriate immune responses. It is approved in more than 37 countries for the treatment of hepatitis B, hepatitis C, and as an adjunct to chemotherapy and various vaccines.
This is problematic, as the optimal immune function is vital to recovery from infection. This is unsurprising when one considers the large role the immune system plays in combating the disease. Its primary function is to stimulate the production of T cells, which are an important part of the immune system. Thymosin also assists in the development of B cells to plasma cells to produce antibodies.
Thymosin Alpha-1 Info Sheet
The predominant form of thymosin, thymosin beta 4, is an actin, a cell building protein. One of the main mechanisms of action of Thymosin Beta-4 is its regulation of Actin. This cell-building protein is an essential component of cell structure and movement which leads to its role in tissue repair. Inflammation plays a large role in many of the symptoms associated with a number of other conditions i. It has been utilized in the management of various inflammatory conditions, as well as part of treatment following a heart attack due to its cardio and neuroprotective effects.
It can be taken on its own or in conjunction with an existing therapy, making it a versatile and valuable peptide. Benefits of Thymosin-alpha 1: Enhances the function of certain immune cells called T and dendritic cells Help eradicate the unhealthy cells and stop the infection or cancer growth Exhibits antibacterial and antifungal properties Suppresses tumor growth Increases vaccine effectiveness Protects against oxidative damage Additional Information: T cells, for example, come in two forms: killer and helper T cells.Thymosin is a synthetic version of a naturally occurring hormone that circulates inside your thymus.
Thymosin alpha-1 is an injectable synthetic hormone that is being studied for hepatitis B, lung and neck cancer, and as an immune-modulator in AIDS. Results from a very small Italian trial suggest that thymosin in combination with an anti-retroviral and low dose alpha-interferon may result in increased T cells. How the four thymic hormones shape this process is not understood or agreed upon yet. Long overlooked by researchers, the thymus is in fact a critical part of your immune system: it's where individual T cells are tailored to respond to the millions of bacteria or fungi or viruses that could invade your body during your lifetime.
Interest in thymosin stems mostly from the results of a few small clinical trials and its strong safety profile. Since then, taking thymosin has been reported to increase 1 IL- 2 and alpha interferon receptors on T cells, 2 thymic maturation of T cells and 3 production of IL-2, gamma interferon, and alpha interferon.
It may increase the number and activity of NK natural killer cells. Why AZT? The theory here is to take AZT or another anti-retroviral to lessen the chance that increasing T cells will result in increased HIV replication at the same time. How thymosin interacts with interferon is a mystery. One theory is that they synergize and work together to improve immune function.
Others, noting similar viral load drops and T cell increases with high-dose alpha interferon and AZT, theorize that thymosin boosts interferon's antiviral activity.
If that's true, it's good news given the side effects of alpha interferon. Hepatitis: The mechanism of action for treating hepatitis has yet to be spelled out.
Small studies phase II studies abroad showed thymosin to be a much safer alternative to the standard treatment, alpha-interferon, with similar or better efficacy.
A recent phase III trial yet to be published in people with chronic hepatitis B has reported disappointing results: an equal number of participants on drug and placebo cleared hepatitis DNA from their blood. It is interesting that twice as many people on placebo as expected cleared virus from their blood. Until we see the data or hear from other studies, we don't know much. Thymosin appears to be quite well tolerated. No adverse drug interactions have been observed. No side effects, other than irritation or a burning sensation at the site of injection, have been seen to date.
Hepatitis B or C doses used in the clinical studies have been either 1 or 1. Once mixed, thymosin is only stable for two days. Suggested dosing schedule: Monday-Thursday or Tuesday-Friday. Keep it refrigerated at all times. Preparation : Please ask your doctor for instructions and go over this process with him or her. Thymosin alpha-1 needs to be mixed before you can inject it. When you receive your order of thymosin, it should contain a small bottle with white powder thymosin and a glass vial of sterile water.
Peptide Therapy: What is Thymosin Beta 4?
Open the vial of sterile water and withdraw it via a needle. Gently pull off the aluminum cover to the thymosin bottle, and poke the needle through the rubber membrane in the top of the bottle. Inject the water into the bottle and swish it around to mix the thymosin and the water. If you are using your own sterile water, inject 1 ml of sterile water into the thymosin bottle. Thymosin is a subcutaneous injection, namely, just below the skin. After injecting the thymosin, store it in the refrigerator.
Use a clean needle each time you inject thymosin. Re-cap the needles carefully and dispose of carefully - get a red hazardous waste basket for your needles. Ask your doctor or get one from a home care company who will also pickup on a regular basis.
Home care companies always provide hazardous waste baskets and pick them up.TB is the synthetic version of a powerful protein known as Thymosin Beta As such, TB has potent healing properties that facilitate a speedy recovery from injuries. TB- basically regulates the process through which actin builds cells in the body.
Actin is a protein that plays a huge role in the formation of muscle cells and it works together with myosin to build metabolism and improve motion. The powerful combination of these peptides has the ability to promote positive cell growth, speed up the healing process and encourage cell migration and proliferation.
This translates to the build-up of good inflammation that actually aids in faster healing. TB is a very agile protein that can travel through the bloodstream faster than most of the other proteins. This is part of what makes it so effective at targeting specific injuries, whether acute or chronic. Of course, it comes with added benefits too like reduced inflammation, better flexibility and even improved hair growth!
The type of high-level activity that athletes go through can put a lot of strain on the heart so if these rumors are proven true it would be good news for the industry. However, research is still underway to fully establish the effects of TB on ventricular hypertrophy which is another word for damaged heart tissue. While TB is not necessarily recognized as a prescription veterinary drug, the racehorse industry has found numerous uses for it.
Most trainers give it to their horses in order to prevent injuries or muscular adhesions ahead of competitions. MedivetEquine reports that TB has the ability to positively affect mammals of all sizes in positive ways. In humans, TB is taken in the form of an injection and has been used to speedily heal wounds and injuries that would otherwise take months to recover from.
You can use intravenous, intramuscular or subcutaneous injections to deliver TB into your bloodstream. This will help speed up absorption and make the peptide more effective. The recommended dosage of TB is anything between 4 to 10 milligrams taken twice weekly. This is the initial dose which should be taken for the first 4 to 6 weeks in order to get your system used to it.
After that, you can take half of that amount once per week for maintenance purposes. This latter stage of the protocol can be taken during the training season and even while you prepare for competitions. It will aid in faster recovery and help you stay injury free as you push your body past its limits.
Experts recommend basing TB dosage protocol and overall length of therapy on the unique needs of the particular animal. Current research on TB shows contradictory results. There are studies which reveal that it can exacerbate cancer cell growth, while other studies say that it actually prevents cancer.
But, further research showed that the presence of Thymosin Beta-4 boosted the production of white blood cells. The most common side-effect that has been observed by athletes and bodybuilders who use this peptide is that of extreme tiredness. Others report experiencing a head rush immediately after injecting it, but the feeling only lasts for a few minutes before things return to normal. Both of these peptides are known for their ability to facilitate quick recovery from wounds and injuries.
The difference between the two lies in their origin. This peptide works to naturally heal ulcers and improve digestion.
Therefore, taking BPC aids in the recovery of the connective tissues that are affected when an injury occurs, and it promotes gastrointestinal health. Its effect is comparable to that of Thymosin Beta-4 in this regard. With that said, TB has received far better reviews for its overall benefits on muscle tissue when compared to BPC In fact, it has even been suggested that TB is on the same level as Thymosin Beta Nevertheless, these two peptides work really well together which is why some athletes prefer to stack them in order to maximize results.
How you use it, however, is entirely up to you.Thymosin Alpha-1, a naturally occuring 28 amino acid thymic peptide is a biological response modifierthat has been introduced to the market in recent years to treat various diseases. Thymosin alpha1 was isolated from the thymic tissue in the mid-sixties and has gained considerable attention for its immunostimulatory activity. This endogenous peptide has also led to its application to diverse pathological conditions, including cancer.
Thymosin Alpha-1 is available in an injection form and is available with a prescription from a specialist or your primary care physician. The lyophilized powder is reconstituted with bacteriostatic water prior to use. Depending on the treatment protocol, Thymosin Alpha-1 injections are administered subcutaneously, twice per week, for the best results.
Injections are administered by doctors, specialists, or patients can self-administer at home as instructed by their physician. Patients taking other medication or on other treatments should discuss with their doctor or a specialist prior to administering Thymosin Alpha Thymosin Alpha-1 enhances the function of certain immune cells called T and dendritic cells.
This function helps eradicate unhealthy cells and stop the infection or cancer growth. Thymosin is a hormone that is produced by the thyroid, meaning it is naturally recurring in the body, making it appropriate for use in an injection form for most patients who suffer from these conditions.
Thymosin is responsible for the development of the production of disease-fighting T-cells. Individuals who suffer from certain thyroid conditions might also benefit from using Thymosin Alpha-1 injections regularly. Thymosin also assists in the production of B-cells to plasma, which helps the body produces antibodies to fight off certain illnesses and ailments. Those who are deficient in the production of thymosin can also benefit from injections administered by their doctor or a specialist, to help the body build up necessary antibodies to protect the immune system.
Common side effects experienced with the administration of this peptide injection include. Individuals who are taking other medication should consult their doctor if they experience these, or other side effects when using Thymosin Alpha-1 injections. No two individuals will react the same when using Thymosin Alpha-1 injections as a treatment for different chronic conditions or deficiencies.
This article is meant for informational purposes only.Thymosins are small proteins present in many animal tissues. They are named thymosins because they were originally isolated from the thymusbut most are now known to be present in many other tissues.
In relation to diseases, thymosins have been categorized as biological response modifiers. The discovery of thymosins in the mid s emerged from investigations of the role of the thymus in development of the vertebrate immune system. Begun by Allan L. The supposition that the role of the thymus might involve a hormone -like mechanism led to the isolation from thymus tissue of a biologically active preparation.
Known as "Thymosin Fraction 5", this was able to restore some aspects of immune function in animals lacking thymus gland. Fraction 5 was found to contain over 40 small peptides molecular weights ranging from to 15, Da. Although found together in Fraction 5, they are now known to be structurally and genetically unrelated.
When individual thymosins were isolated from Fraction 5 and characterized, they were found to have extremely varied and important biological properties.
However they are not truly thymic hormones in that they are not restricted in occurrence to thymus and several are widely distributed throughout many different tissues. Thymosin beta-4 was allegedly used by some players in various Australian football codes and is under investigation by the Australian Sports Anti-Doping Authority for anti-doping violations. The process of hair growth utilizes many cellular and molecular mechanisms common to angiogenesis and wound healing.
From Wikipedia, the free encyclopedia. Redirected from Thymosins. Prothymosin alpha, parathymosin, and beta-thymosins: structure and function". Vitamins and hormones. Journal of Chromatography A. Retrieved Oxytocin Vasopressin. Thyroid hormones T 3 T 4 Calcitonin Thyroid axis. Testosterone AMH Inhibin. Glucagon Insulin Amylin Somatostatin Pancreatic polypeptide.
Gastrin Ghrelin. Enteroglucagon Peptide YY. Leptin Adiponectin Resistin. Categories : Hormones of the thymus gland Hormones of the immune system. Namespaces Article Talk.
Views Read Edit View history.I'd highly recommend you review that article prior to reading this one. TB is a synthetic peptide that has been directly linked to impressive extremely enhanced recovery times for muscle and more. Since then, Dr. Goldstein founded a company that creates thymosin alpha 1 for the purpose of increasing immune cell activity, and thymosin beta 4 TB to promote wound repair and healing.
TB has been used extensively for race horses to prevent adhesions from forming, although it is not a prescription veterinary drug. Just in case you care about the specifics or you really, really miss high school chemistry class, you can dig into the molecular formula of TB below.
Upregulation of actin allows TB to promote healing, cell growth, cell migration and cell proliferation. These websites can only legally sell the peptides for research purposes. When you get your TB, it will come in a powder form. Once your TB is properly mixed, you then draw the dose into an insulin syringe, and inject it intramuscularly, subcutaneously, or intravenously according to your preference.
Do not let your mixed TB sit at room temperature or in the light or it will go bad. When drawing TB into syringes for injection, turn the bottle upside down slowly and draw the liquid into the syringe smoothly and slowly. When injecting, do so with a smooth, slow motion as well. Peptides are fragile and too much mixing and jostling of the container can damage or reduce the effectiveness of your product. TB can be delivered through subcutaneous, intramuscular, or intravenous injections.
This will minimize your risks for bacteria and contamination. Intravenous injection — the needle is inserted directly into the vein, usually on the wrist, elbow, or back of the hand. After injecting TB, massage the area of injection for about a minute to help work the TB into the tissues and improve the absorption and effectiveness.
For a pound person, the dosage recommendation is about 7. At the risk of sending you down a broscience rabbit hole, here's a link to a bodybuilding forum discussion that delves into TB dosage in more detail, along with some practical user experiences.
You should know that there have been some conflicting research studies about this stuff when it comes to cancer.